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ClinicalTrials.gov is a registry of clinical studies conducted primarily within the United States.
(last updated: Nov 28, 2022)
Clinical Trials Data or Model| Title | Specimen or Dataset Repository | Recruitment | Conditions | Intervention | Gender | Age Groups | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Cross Sectional Study to Evaluate Effects of Kinesiotaping on Muscle Activity During Climbing Stairs and Sport Activity
| Completed | Physical Activity | Device, IQ-Tape, Kinesiotape, No-Tape, Other | Male, Female | 20 Years - 35 Years | N/A | Interventional | This study aims to evaluate the effects of IQ-Tape, Kinesiotaping and no Taping on muscle activity during daily activity and sport activity. | no data available | |
|
The Effect Effect of Empagliflozin on Oxidative Stress in Patients With Type 2 Diabetes
| Completed | Diabetes Mellitus, Type 2 | Drug, Empagliflozin, Placebo | Male | 18 Years - 75 Years | Phase 2 | Interventional | The purpose of this study is to investigate the effect of empagliflozin on oxidative stress in patients with type 2 diabetes. The association is examined by comparing the difference in oxidative modifications before and after 14 days treatment with 25 mg empagliflozin compared to placebo treatment. The study is randomised, double-blinded, and placebo controlled. Each treatment group consists of 17 males with type 2 diabetes. Oxidative modifications are measured by urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine. A student t-test will be performed to compare the drug treatment with placebo. The results will be published in a peer-review journal. | no data available | |
|
Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery
| Completed | Fibrin/Therapeutic Use, Blood Platelets, Molar, Third, Bone Regeneration | Control group, Platelet-rich fibrin, Procedure | Male, Female | 16 Years - 29 Years | N/A | Interventional | The purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin. | no data available | |
|
Evaluation of Algorithms to Identify Incident Cancer Cases by Using French Health Administrative Databases
| Completed | All Cancer Incidence | Incident cancer, Other | Male, Female | N/A - 90 Years | Observational | "This study is a population based observational study conducted on the French administrative databases to estimate cancer incidence in 2012 by using the "ECHANTILLON GENERALISTE DES BENEFICIAIRES" (EGB, a 1/97th dynamic random sample of the SNIIRAM). The EGB database contains anonymous and prospectively recorded data about all beneficiaries' medical reimbursements. Many algorithm definitions are defined to estimate the incident rate of cancer in 2012 from the EGB database. The incidence rates obtained by each algorithm definition are compared to national incidence rates by indirect age and sex standardization. National incidence rates are obtained from "FRANCE CANCER INCIDENCE ET MORTALITE" (FRANCIM): the French network of cancer registries." | no data available | ||
|
Fully Automated Anesthesia, Analgesia and Fluid Management
| Completed | General Anesthetic Drug Overdose, Adverse Effect of Intravenous Anesthetics, Sequela, Complication of Anesthesia, Drug Delivery System Malfunction, Hemodynamic Instability, Underdosing of Other General Anesthetics | BIS XP, Covidien, Ireland, EV-1000 TM, Edwards Lifesciences, Irvine, California, USA, Other | Male, Female | 18 Years - 99 Years | Phase 1 | Interventional | Evaluate the feasibility and quality of automated anesthesia, analgesia and fluid management based on a combination of several physiological variables (bispectral index [BIS], stroke volume [SV], and stroke volume variation [SVV]) using 2 independent physiologic closed-loop systems (PCLS) in patients undergoing high risk vascular surgery | no data available | |
|
Scoliosis and Quality of Life of Adolescents
| Completed | Scoliosis | First time measure, Other, Second time measure, Third time measure | Male, Female | 12 Years - 18 Years | Observational | Around the scoliosis surgery, the pain (pre or post operative, physical, psychological, fantasy or real) is a major concern for adolescents and their families. She is also a key concern of caregivers, both its assessment and management is complex. this pain involved predominantly in the quality of life of these teenagers today who will become the adults of tomorrow. To date in France, no study aims to describe and evaluate the effect of a multidisciplinary approach and its impact on the quality of life of these young people made. The present study wish to prevent, anticipate and limit the short, medium and long-term morbidity. Focus will be on pain and its management, on preparing for surgery, hospitalization, follow-up after surgery, rehabilitation until recovery. Help teens reclaim their bodies after the changes caused by the intervention is a major issue. This study believe that support good quality, adapted to patient needs will limit operating and postoperative pain in the medium and long term. Medical team developed special attention around the teenagers that are operated for scoliosis (teen groups and parent groups, interview before the operation and counseling, physiotherapy support ...). The present study would systematize data collections in order to have a comprehensive and accurate assessment of the care. The qualitative research will focus on the multidisciplinary care in an effort to evaluate the whole course of these teenagers, their experience and to identify efforts to put in place to optimize the current care. | no data available | ||
|
Nutritional Status Of Under-Six Children: Epidemiology Study (NUTRI-STAT)
| Completed | Children Behavior About Nutrition | Male, Female | 4 Years - 6 Years | Observational | This study permit to evaluate the characteristics of children in third year of preschool, during a year, in 16 schools in Thionville (north-eastern France) by the way of the annual medical visit.The aim of the study is to describe the nutritional status of children under-six years of age: underweight, overweight, and obesity considering the sex. . | no data available | |||
Evaluating the Infectivity, Safety and Immunogenicity of a Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccine (RSV LID cp ΔM2-2) in RSV-Seronegative Infants 6 to 24 Months of Age
| Terminated | Respiratory Syncytial Virus Infections | Biological, Placebo, RSV LID cp ΔM2-2 Vaccine | Male, Female | 6 Months - 24 Months | Phase 1 | Interventional | The purpose of this study was to evaluate the safety, infectivity, and immunogenicity of a single intranasal dose of a recombinant live-attenuated respiratory syncytial virus (RSV) vaccine in RSV-seronegative infants 6 to 24 months of age. This study was a companion study to CIR 312. | Available, from April 20, 2018 | |
|
A Prospective Validation Study of a Rapid Point-of-Care Breath Test for Breast Cancer
| Completed | Breast Cancer | Female | 18 Years - N/A | Observational | This is a multicenter, blinded prospective study of 2,000 women undergoing mammography for breast -related symptoms or signs. Breath tests will be performed in order to demonstrate that the outcome of mammography results combined with breast test results improves clinical sensitivity and specificity in a group that has an increased prior probability of cancer. Breath will be collected and analyzed with a rapid point-of-care instrument (BreathLink™) and also with a laboratory-based assay of samples collected into an inflatable bag (BreathBag™). | no data available | |||
|
High-Concentration Nitrous Oxide for Dental Procedural Sedation in Children
| Unknown status | Anxiety | Drug, Nitrous Oxide | Male, Female | 3 Years - 15 Years | N/A | Interventional | The use of nitrous oxide as a sedative agent is very common in pediatric dentistry. In concentrations up to 50% it is considered as mild sedation and it is very safe. Despite its safety and widespread of its use nitrous oxide is not a potent drug and many times dentists fail to gain cooperation in moderate or high anxious children, and the alternatives are to use moderate sedation with drugs such as Midazolam, Atarax or general anesthesia. Higher concentration was not conducted in Pediatry densitery. The aim of this study is to compare the effectivity and safety of providing nitrous oxide at increasing concentrations 60%, 70% with 50% parameters, sedation depth, adverse events and cooperation of the child during the dental treatment.Our hypothesis is that nitrous oxide in concentrations higher than 50% up to 70% is a safe and effective sedation method in dental treatment of children. | no data available | |
|
Nonneoplastic Epithelial Disorders of Vulva and High Intensity Focused Ultrasound
| Unknown status | Vulva Intraepithelial Nonneoplastic | Device, Drug, Fu Tiankang disposable vaginal filling suppository, Albothyl (Policresulen Solution) , and the gynecologic medical antimicrobial dressing gel (chitosan gel)., the high intensity focused ultrasound (Mianyang Sonic electronic LLC) | Female | 18 Years - 78 Years | N/A | Interventional | Nonneoplastic epithelial disorders of skin and mucosa of vulva refer to a group of chronic diseases shown as female genital skin and mucosal tissue degeneration and pigmentation change. The main symptoms are vulval itching, squamous cell hyperplasia, vulval and perianal skin atrophy or thinning, hypopigmentation. The current treatments are primarily local drug or surgical treatments. However, the effect is not good enough, but the diseases often recur and severely affect patients' quality of life. In this study, the investigators combined the technology of high intensity focused ultrasound (HIFU) (ultrasound device made by Mianyang Sonic electronic LLC, Mianyang China, registration number: 2005-2230099} with special drug to treat. The data from colposcopy and biopsy pathology were collected before and after treatment to create the objective identifying degree of the disease by with "grading methods" and evaluate the treatment effect. At the meantime, the standardized treatment procedure, methods and efficacy criterion were all stipulated to achieve satisfactory results, which could be used to clinical treatments. So far, the investigators have not seen similar study reported internationally. | no data available | |
|
Sildenafil Effect After Ovulation Induction
| Unknown status | Infertility | Clomiphene citrate, Drug, Placebo, sildenafil citrate | Female | 18 Years - 35 Years | Phase 4 | Interventional | 100 women with infertility classified into 2 groups. Group A: Included 50 women who will be given clomiphene citrate 50mg (clomid) orally 2 times/day from 2rd-7th day of the cycle and sildeaynafil citrate 20mg tab from 7th-11th day of the same cycle orally 3 times/day. Group B: Included 50 women who will be given clomiphene citrate 50mg (clomid) orally 2 times/day from 2rd-7th day of the cycle and placebo tablets from 7th-11th day of the same cycle orally 3 times/day. | no data available | |
|
Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases:
| Completed | Systemic Autoimmune Diseases | Male, Female | 18 Years - N/A | Observational | Connective tissue diseases (CTD) or systemic autoimmune diseases (SADs) as they are known today are a group of chronic inflammatory conditions with autoimmune aetiology with few treatment options and difficult diagnosis.Brest team contribute to perform a new classification of the following systemic autoimmune diseases in a European Union's Seventh Framework Programme. The aim of this research is to reclassify the individuals affected by SADs into molecular clusters instead of clinical entities through the determination of molecular profiles using several "Omics" techniques. | no data available | |||
|
Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility
| Unknown status | Insulin Sensitivity | Artificially sweetened beverages, Dietary Supplement, Sugar sweetened beverages | Male, Female | 25 Years - 45 Years | N/A | Interventional | This study will compare the effect of acute consumption of two carbonated drinks, sweetened with sugar or with non-caloric sweeteners, over the insulin response of healthy adults who normally consumed foods or drinks that contain non-caloric sweeteners | no data available | |
|
Observational Study of Patients With Subarachnoid Hemorrhage
| Unknown status | Subarachnoid Hemorrhage | Male, Female | 18 Years - N/A | Observational | This prospective, observational study aim to identify : - Prognostic factor of patients with subarachnoid haemorrhage in neuro intensive care unit - The impact of standard therapeutic used (surgery, embolization ; medical treatment of vasospasm ; treatment of complications like hyponatremia, stress myocardiopathy, …) | no data available | |||
|
Efficacy and Safety Study of Cediranib in Combination With Olaparib in Patients With Recurrent Platinum-Resistant Ovarian Cancer
| Completed | Recurrent Platinum Resistant Ovarian Cancer | cediranib and olaparib, Drug | Female | 18 Years - 120 Years | Phase 2 | Interventional | This is an open label, single arm, multi-center study to assess the efficacy and safety of the combination of cediranib and olaparib tablets in platinum-resistant relapsed high grade serous, high grade endometroid or clear cell ovarian, fallopian tube or primary peritoneal carcinoma patients who have received at least 3 prior lines of chemotherapy and who do not carry deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA) mutations. | Available, from July 21, 2020 | |
|
High-intensity Training in an Enriched Environment in Late Phase After Stroke
| Completed | Stroke, Brain Diseases | Other, UC + ETT | Male, Female | 18 Years - 90 Years | N/A | Interventional | We designed an explorative clinical study to assess the effectiveness of an enriched intense and task-oriented therapy program in enhancing motor recovery in patients with moderate to moderately severe hemiplegia after stroke. This enriched comprehensive task-specific therapy (ETT) program combines intensive and task-specific therapy with the sensory-motor, social, and cognitive stimulation inherent to environmental enrichment. We also investigated whether ETT improves gait, balance, upper and lower limb function, and confidence in task performance, health-related quality of life (HRQoL) and reduces fatigue and depression. | no data available | |
|
Filgotinib in Combination With Methotrexate in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate
| Completed | Rheumatoid Arthritis | Adalimumab, Drug, Filgotinib, MTX, Placebo to match adalimumab, Placebo to match filgotinib | Male, Female | 18 Years - N/A | Phase 3 | Interventional | The primary objective of this study is to evaluate the effects of filgotinib versus placebo for the treatment of signs and symptoms of rheumatoid arthritis (RA) as measured by the percentage of participants achieving an American College of Rheumatology 20% improvement response (ACR20) at Week 12. | Available, from December 21, 2020 | |
|
IMCgp100-401 Rollover Study
| Terminated | Malignant Melanoma | Drug, IMCgp100 | Male, Female | 18 Years - N/A | Phase 2 | Interventional | IMCgp100-401 is a rollover study that is designed to provide continued access to IMCgp100 for eligible participants with advanced melanoma who have previously participated in an IMCgp100 study (parent study). | Available, from April 22, 2020 | |
|
When Asking the Indication of a Skin Biopsy From a Patient With a Leg Ulcer in Primary Care?
| Completed | Varicose Ulcer, Leg Ulcer | No intervention only description, Other | Male, Female | N/A - N/A | Observational | Leg ulcers are frequent. There are no epidemiological studies available in France, but international studies estimate the prevalence between 0.045 and 0.63% of the total population, prevalence increases with age, reaching 5% of patients over 80 years. Extrapolating these prevalences in the French population between 28 000 and 395 000 people are affected in France a leg ulcer. It is a costly disease. In 2001, a French study conducted among 800 physicians, including 85.7% of general practitioners, involving more than 1000 patients with venous ulcers, it was estimated that the total cost of treatment per patient average was 888 32 euros. This is truly a public health problem. Leg ulcers are in 80% of cases of vascular causes (venous, arterial or arteriovenous mixed). However, there are rare causes of ulcers: skin carcinoma, infectious ulcers and vasculitis. These ulcers rare causes require specific treatments that can often heal. To diagnose, to perform a skin biopsy. Thus, the general practitioner must know when to put the indication for biopsy of a leg ulcer. | no data available |
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