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Dear dkNET Community,
dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.
dkNET News
dkNET Office Hours Are you ready for the new NIH Data Management and Sharing Plan (effective January 25, 2023)? Do you have questions or need help? Attend dkNET Office Hours on Friday, Mar. 3, 2023, 11 am - 12 pm PT! Dr. Jeffrey Grethe, dkNET co-PI and expert on Data Management and Sharing, Dr. Rebecca Rodriguez, the Repository Program Director at NIDDK, Ms. Reaya Reuss, Chief of Staff to the Deputy Director at NIDDK, and the support team members from the NIDDK Central Repository, will be available to answer your questions. Link: https://dknet.org/about/blog/2585
Upcoming dkNET Webinars: dkNET New Investigator Pilot Program in Bioinformatics Awardee Webinar Series (1) “Estimating Relative Beta-Cell Function During Continuous Glucose Monitoring” presented by Dr. Joon Ha on Friday, Mar. 10, 2023, 11 am - 12 pm PT: https://dknet.org/about/blog/2589 (2) “Single Molecule Spatial Transcriptomics: Interpreting the Spatial Expression of RNAs from FISH Images” presented by Dr. Jing Liu on Friday, Apr. 21, 2023, 11 am - 12 pm PT: https://dknet.org/about/webinar
Recordings and Slides are Now Available: (1) dkNET Office Hours - "Are You Ready for 2023: New NIH Data Management and Sharing Mandates" on Jan. 13, 2023: Slides; Recording. (2) FAIR Data Curation of Antibody/B-cell and T-cell Receptor Sequences in the AIRR Data Commons on Jan. 27, 2023: Slides; Recording. (3) Choosing Sample Sizes for Multilevel and Longitudinal Studies Analyzed with Linear Mixed Models on Feb. 10, 2023: Slides; Recording. (4) dkNET Pilot Program Awardee Webinar Series “Postpartum Glucose Screening Among Homeless Women with Gestational Diabetes” on Feb. 24, 2023: Slides; Recording.
NIDDK Released Data Management & Sharing (DMS) guidance, tools, and resources webpage: https://www.niddk.nih.gov/research-funding/research-resources/data-management-sharing. Don’t forget to check it out while writing your DMS plan!
Congratulations to our 2022 dkNET New Investigator Pilot Program in Bioinformatics Awardees: Drs. Joon Ha, Jing Liu, Nabil Rabhi, Rie Sakai-Bizmark, and Wenting Wu. Join our dkNET Pilot Program Awardee Webinar Series this Spring to learn more about their project!
The 2023 dkNET Summer of Data Student Program is a 6-week program providing an opportunity for students (high school to Masters/ PhD graduate) to learn rigor and reproducibility practices, FAIR data management, & dkNET resources and apply them to their research projects! dkNET is accepting applications now! This program requires that students be involved with an NIDDK-related research lab during the summer of 2023. dkNET offers limited scholarships to student applicants. Application due date: Apr. 24, 2023.
A new episode is released from BioTechniques! In this interview, dkNET Co-PI Dr. Maryann Martone discussed open science and the meaning of FAIR. Check it out now! https://www.biotechniques.com/podcasts/talking-techniques-open-neuroscience-and-the-meaning-of-fair
Events in March 2023
Mar. 03, 2023
dkNET Office Hours - "Are You Ready for 2023: New NIH Data Management and Sharing Mandates" on March 3, 2023
For all proposals submitted on/after January 25 2023, NIH requires data sharing from all NIH-funded studies. Do you have appropriate data management practices and sharing plans in place to meet these requirements? Have questions or need some help? Join the dkNET office hours to learn about NIH’s policy (NOT-OD-21-013) and available resources that could help.
In our upcoming session on March 3, 2023, we are pleased to invite Dr. Jeffrey Grethe, dkNET co-PI and expert on Data Management and Sharing, Dr. Rebecca Rodriguez, Repository Program Director at NIDDK, Ms. Reaya Reuss, Chief of Staff to the Deputy Director at NIDDK, and the support team members from the NIDDK Central Repository. They will be available to answer any questions you may have.
More information: https://dknet.org/about/blog/2585
Mar. 08-09, 2023
NIDDK Unraveling the Secrets of the (Renal) Interstitium Webinar
Registration deadline: March 7, 2023
More information: https://www.niddk.nih.gov/news/meetings-workshops/2023/unraveling-the-secrets-of-the-renal-interstitium
Mar. 08, 2023
Diabetes Research Virtual Seminar Series: What Goes Wrong with the Beta Cells in Diabetes?
More information: https://diabetes-virtual-seminar.org/
Mar. 10, 2023
dkNET Webinar: Estimating Relative Beta-Cell Function During Continuous Glucose Monitoring and Its Clinical Applications
dkNET New Investigator Pilot Program in Bioinformatics Awardee Webinar Series
Join dkNET Webinar on Friday, March 10, 2023, 11 am - 12 pm PST
Presenter: Joon Ha, PhD. Associate Professor, Department of Mathematics, Howard University, Washington DC.
Abstract
The most common form of diabetes, type 2 diabetes (T2D) is a failure of insulin-secreting pancreatic beta-cells to increase insulin to the level required to maintain normal blood glucose. Thus, identifying beta-cell function and insulin sensitivity in those who are at high risk is crucial to preventing and delaying the disease. Hyper-glycemic clamp and euglycemic hyper- insulinemic clamp are considered to be gold standard measures for these quantities. However, these two methods demand highly skilled labor and thus are cost-prohibitive. Glucose challenge tests have been used to estimate beta-cell function and insulin sensitivity. The product of beta-cell function and insulin sensitivity, termed the disposition index (DI), is of great value because it measures beta-cell function relative to insulin requirements. However, glucose challenge tests are expensive and time-consuming and therefore impractical to implement in large-scale clinical studies. To address this challenge, we developed a model disposition index (mDI estimated without insulin) that does not require insulin measurements during an oral glucose tolerance test (OGTT) (Ha et al., Diabetes 2021 (70) suppl. 1). mDI outperforms the conventional oral disposition index (oDI) at predicting progression to diabetes.
To further increase access and refine the assessments of beta-cell function, we are adapting our model to calculate a model disposition index using continuous glucose monitoring (CGM). CGM has been in the spotlight of diabetes management and has revolutionized the field of medicine as they are approved for glucose monitoring and clinical decision-making in patients with diabetes. CGM devices are relatively inexpensive compared to oral glucose challenge tests, accessible, and simple to use, especially in remote or free-living environments. The CGM device continuously measures interstitial glucose every 5 minutes and provides glucose profiles for 7-14 days. Thus, there are numerous data points compared to glucose challenge tests, but the abundant data points have not previously been used for estimating metabolic parameters. We compared mDI to two widely used CGM-derived metabolic parameters for assessing metabolic status and risk, mean glucose and glycemic excursion. Both mean glucose and glycemic excursion correlated strongly with mDI. The new approach promises to be cost- effective and easy to perform and therefore implementable in large-scale clinical studies. As for specific clinical applications, estimated model parameters during OGTTs identified ethnic differences in common pathways to T2D between Pima Indians and Koreans.
More information: https://dknet.org/about/blog/2589
Mar. 12-17, 2023
Gordon Research Conference: Examining the Intersection Between Systemic and Cellular Metabolism and Lifestyle Factors to Understand Health and Disease
The Metabolomics and Human Health GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field. Metabolomics is the comprehensive study of the metabolome, the repertoire of metabolites present in cells, tissues, and body fluids. More recently, these metabolites are being implicated in the promotion of human health. The human metabolic profile is influenced by a number of factors including diet, genetics, environmental factors and the microbiome. Understanding the influence of these factors at a cellular and systemic level is key to deciphering the role of metabolites in human health and promotion of lifespan.In this Gordon Conference series, we highlight state of the art metabolomics technologies and how such technologies can be used to study Human health. The conference will cover exciting new applications in the field such as Precision Nutrition, Human Ageing, response to Therapies (Precision Medicine), Exposome and Human Health. Application deadline: Feb. 12, 2023.
Location: Lucca, 55100 Lucca, Province of Lucca, Italy
More information: https://www.grc.org/metabolomics-and-human-health-conference/2023/
Mar. 19-23, 2023
Keystone Symposia: Metabolic and Molecular Mechanisms of NAFLD/NASH
Location: Banff, AB, Canada
More information: https://www.keystonesymposia.org/conferences/conference-listing/meeting?eventid=6913
Mar. 27, 2023
NIDDK NMRI Annual Workshop 2023
Location: Bethesda, MD, USA
More information: https://www.niddk.nih.gov/news/meetings-workshops/2023/nmri-annual-meeting-2023
Mar. 29, 2023
NLM Training: Standardize Your Research with the NIH Common Data Element Repository
Through live demonstrations and hands-on exercises, this course will introduce you to common data elements (CDEs) and the NIH Common Data Element Repository (CDE-R). The course begins with an in-depth introduction to what CDEs are and examples of how researchers are already using them. Then, you’ll see how to search the repository and practice searching on your own. Subject matter experts will be in attendance to answer your questions.
Consider attending this course if you:
More information: https://nih.zoomgov.com/webinar/register/WN_ZEGtd7yUR7uyIhCvh9GupQ
Funding Opportunities Information and Deadlines in March 2023
Mar. 01, 2023
HHMI Funding Opportunity Application Deadline: The Howard Hughes Medical Institute (HHMI) Opens National Competition for Investigator Program
The Howard Hughes Medical Institute (HHMI) is announcing a national open competition to appoint approximately 25 new Investigators. This effort will expand HHMI’s community of more than 260 Investigators who perform basic biological research at about 60 research institutions across the nation. Each HHMI Investigator will receive roughly $8 million over a seven-year term, which is renewable pending favorable scientific review. HHMI encourages Investigators to push their research fields into new areas of inquiry.
More information: https://www.hhmi.org/news/hhmi-opens-national-competition-investigator-program
Mar. 01, 2023
NIH Funding Opportunity Application Due: Enhancing the Use of the All of Us Research Program’s Data (R21 Clinical Trial Not Allowed)
The All of Us Research Program (All of Us) within the Office of the Director (OD) encourages investigators to apply for grant awards that will advance research in high-priority mission areas of the Institutes, Centers, and Offices (ICOs) through two companion FOAs (1) one to use standard methods and approaches to analyze currently available data within the All of Us Research Program’s Researcher Workbench and (2) one to develop new methods, models, and tools and use them to analyze data in the Researcher Workbench. The new tools will be made broadly available to the scientific community. This FOA uses the R21 grant mechanism for new tool development and application, while the companion FOA (link) uses the R03 grant mechanism to support data analysis using standard methods. Application Due Date: Mar. 1, 2023.
More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-pm-23-001.html
Mar. 01, 2023
NIH Funding Opportunity Application Due: Small Grants to Enhance the Use of the All of Us Research Program’s Data (R03 Clinical Trial Not Allowed)
The All of Us Research Program (All of Us) within the Office of the Director (OD) encourages investigators to apply for grant awards that will advance research in high-priority mission areas of the Institutes, Centers, and Offices (ICOs) through two companion FOAs (1) one to use standard methods and approaches to analyze currently available data within the All of Us Research Program’s Researcher Workbench and (2) one to develop new methods, models, and tools and use them to analyze data in the Researcher Workbench. The new tools will be made broadly available to the scientific community. This FOA uses the R03 grant mechanism to support data analysis using standard methods, while the companion FOA (link) uses the R21 mechanism for new tool development and application. Application Due Date: Mar. 1, 2023.
More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-pm-23-002.html
Mar. 02, 2023
NIDDK Funding Opportunity Application Due: NIDDK Central Repository Non-renewable Sample Access (X01 Clinical Trial Not Allowed)
Mar. 07, 2023
NIH Funding Opportunity Application Due: HEAL Initiative: Development and Validation of Non-Rodent Mammalian Models of Pain (R01 Clinical Trial Not Allowed)
Mar. 08, 2023
NIDDK Funding Opportunity Application Due: Fostering Research With Additional Resources and Development (FORWARD) Urology Centers
More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-dk-22-027.html
Mar. 09, 2023
NIH Funding Opportunity Application Due: HEAL Initiative: Discovery and Functional Evaluation of Human Pain-associated Genes & Cells (U19 Clinical Trial Not Allowed)
Mar. 09, 2023
NIDDK Funding Opportunity Application Due: Ancillary Studies to the NIDDK Inflammatory Bowel Disease Genetics Consortium (R01 Clinical Trial Not Allowed)
More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-dk-22-023.html
Mar. 17, 2023
NIH Funding Opportunity Letter of Intent Due: Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences
More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-od-23-003.html
Mar. 20, 2023
NIDDK Funding Opportunity Letter of Intent Due: New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)
Mar. 24, 2023
NIH Funding Opportunity Application Due: Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional)
More information: https://grants.nih.gov/grants/guide/pa-files/par-23-112.html
Mar. 24, 2023
NIH Funding Opportunity Application Due: Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional)
This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications that propose t ...[more] |
Mar. 30, 2023
NIDDK Funding Opportunity Application Due: KUH Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 - Independent Clinical Trial Not Allowed)
Mar. 31, 2023
NIDDK Funding Opportunity Application Due: Human Islet Research Network (HIRN) Pancreas Knowledgebase Program (PanKbase) (U24 - Clinical Trial Not Allowed)
Mar. 31, 2023
NIDDK Funding Opportunity Application Due: NIDDK Information Network Coordinating Unit: dkNET-CU
More information: https://dknet.org/about/dknetnews/2527