We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Software for analysis to determine live versus dead cells – no fluorescent dyes needed.
Web tool for identification and characterization of channels in transmembrane proteins from their three-dimensional structure.
Provides catalogue of confirmed and predicted DNA replication origin sites. At present this is limited to budding yeast and fission yeast. Data have been collated as culmination of number of genome-wide studies to identify location of replication origins throughout budding yeast genome. In addition to genome-wide studies data from large number of other origin mapping and characterization studies have been included.
Provides cytometry services featuring sorting and analyzing. For analysis, we currently have BD LSR Fortessa, BD FACSymphony A3, and Cytek Aurora. Our cell sorters include 14-parameter, 4-laser Sony MA900 and 16-parameter, 5-laser FACSAria dedicated to BSL3 cell sorting.
Software pipeline is set to to non-model plant GO/KO function annotations using R. It can collect data from Eggnog-mapper of custom BLAST, convert data, and make OrgDB packages.
Core operates 12 clean rooms and focuses on IND manufacturing under cGMP/cGTP. Operations are monitored 24/7 by expert staff. Specializes in and collaborates on preclinical research development involving process conceptualization, technology transfer and testing implementation on human cell-based drugs for clinical trials. Immunological monitoring services are available to support clinical trials. The facility is a FACT-, CLIA-, CAP-, and FDA-accredited laboratory.
Supports analytical cytometry and cell sorting. Offers NanoString Digital Spatial Analyzer and nCounter service and support.
Provides novel quantitative imaging techniques that trace biomarkers of molecular events associated with effective cancer therapy.
Expertise resides in micro and nanotechnology, sensors, transducers, microelectromechanical systems (MEMS), advanced materials, biomedical devices, space and governmental applications.Offers SEM and TEM imaging services for biological samples.
Provides bioanalytical, pharmacokinetic and pharmacology research services that support preclinical and clinical research programs focused on oncology. Resources include HPLC-UV/fluorescence, ICP-MS, LC-MS/MS, LSC, ELISA, and in vivo rodent procedures, as well as advanced PK software suites and expertise for preclinical and clinical projects.
Supports genomics and transcriptomics platforms including nucleic acid extraction, sample QC, next-generation library preparation and sequencing. Specializes in paraffin-embedded tissue samples.
Provides bioinformatics support for translational genomics using sequencing, arrays, single cell, and other technologies.
Provides statistical and computational methods for design, execution, analysis, and reporting of cancer-related research studies and trials including biomarker analysis and grant development.
Light microscopy core facility at Newcastle University based in the Faculty of Medical Sciences, providing services, access, training and support for light microscopy.
Software tool for single cell WGS analysis. Used to accurately detect single base substitutions, insertions-deletions (indels), and structural variants in PTA-based WGS data.
SeqStudio Genetic Analyzer is fluorescent dye labeled genetic analysis system using capillary electrophoresis technology. Enables both sequencing and fragment analysis applications without the need to switch polymer type or capillary array length. Allows to perform both sequencing and fragment analysis in single run.
Software tool to detect phenotypically relevant drug targets through unique transcriptomic enrichment that emphasizes biological directionality of drug-derived gene sets. Exploratory tool to screen for possible drug targeting molecules.
Software error correction and de-novo assembly tool for Nanopore long noisy reads. Nanopore data assembler.
Software tool as long-read mapping algorithm optimized for mapping ONT and PacBio reads to repetitive reference sequences. Winnowmap2 computes each read mapping through collection of confident subalignments. This approach is more tolerant of structural variation and more sensitive to paralog-specific variants within repeats.
Software R package to estimate distribution values for temporal node constraints and prepare input files for MCMCtree. Helps users choose parameters to reflect age information for prior age distributions, visualise time priors, and produce output files ready to be used in MCMCtree. Used to prepare MCMCtree analyses and visualize posterior ages on trees.